Fåhraeus L, Larsson-Cohn U, Ljungberg S, Wallentin L
Fertil Steril. 1984 Jul;42(1):52-7. doi: 10.1016/s0015-0282(16)47957-4.
Twelve women with pelvic endometriosis were treated with 600 mg of danazol daily for 24 weeks. The molar and fractional lecithin:cholesterol acyl transfer (LCAT) rates and the concentrations of cholesterol, phospholipids, and triglycerides were determined in plasma and in the very low-density lipoprotein, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and HDL2 and HDL3 fractions before, during, and after the medication. After 2 weeks the HDL, HDL2, and HDL3 cholesterol concentrations were reduced by 49%, 73%, and 29%, respectively, while the LDL level was increased by 14%. The molar and fractional LCAT rates decreased during treatment, and these reduced LCAT rates are consistent with a reduced fractional LDL removal. Within 8 weeks after cessation of medication, all parameters had returned to the pretreatment levels.
12名患有盆腔子宫内膜异位症的女性每天服用600毫克达那唑，持续24周。在用药前、用药期间和用药后，测定血浆以及极低密度脂蛋白、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、HDL2和HDL3组分中的摩尔比和分数卵磷脂：胆固醇酰基转移（LCAT）速率以及胆固醇、磷脂和甘油三酯的浓度。2周后，HDL、HDL2和HDL3胆固醇浓度分别降低了49%、73%和29%，而LDL水平升高了14%。治疗期间摩尔比和分数LCAT速率下降，这些降低的LCAT速率与分数LDL清除率降低一致。停药后8周内，所有参数均恢复到治疗前水平。
