Gopinath C, Thuring J, Zayed I
Br J Exp Pathol. 1978 Apr;59(2):148-57.
Subcutaneous injections of isoprenaline sulphate in dogs (1-3 mg/kg) resulted in myocardial injury. Good correlation was observed between abnormal ECG recordings, serum enzyme concentrations and myocardial lesions in the acute phase of injury. However, in cases where less extensive myocardial injury was produced due to lower doses of isoprenaline or in cases of the reparative phase of the isoprenaline-induced myocardial injury, serum enzymes were not useful indicators of the change. Similary, ECG recordings taken peripherally also did not show alteration in the reparative phase of the injury in spite of extensive myocardial lesions.
给狗皮下注射硫酸异丙肾上腺素（1 - 3毫克/千克）会导致心肌损伤。在损伤急性期，心电图记录异常、血清酶浓度与心肌损伤之间观察到良好的相关性。然而，在因异丙肾上腺素剂量较低导致心肌损伤较轻的情况下，或在异丙肾上腺素诱导的心肌损伤修复期，血清酶并非损伤变化的有用指标。同样，尽管心肌损伤广泛，但外周记录的心电图在损伤修复期也未显示出改变。
