Swanberg L, Tuazon C U
Am J Med Sci. 1984 May-Jun;287(3):49-54. doi: 10.1097/00000441-198405000-00018.
Eight patients with serious staphylococcal infections such as endocarditis, meningitis, epidural abscess, shunt and graft infections were treated with nafcillin, cephalothin or vancomycin in combination with rifampin. In vitro antibiotic sensitivities demonstrated that the Staphylococcus aureus and Staphylococcus epidermidis were highly sensitive to rifampin with minimum inhibitory and bactericidal levels of .0078-.25 micrograms/ml. In all patients reviewed and reported, when serum bactericidal levels were measured before and after the addition of rifampin, there was a positive correlation between microbiological and clinical outcome. Thus, in selected patients with life-threatening infections caused by S. aureus and S. epidermidis rifampin should be considered an adjunctive therapy.
8例患有严重葡萄球菌感染（如心内膜炎、脑膜炎、硬膜外脓肿、分流及移植物感染）的患者接受了萘夫西林、头孢噻吩或万古霉素联合利福平治疗。体外抗生素敏感性试验表明，金黄色葡萄球菌和表皮葡萄球菌对利福平高度敏感，最低抑菌浓度和杀菌浓度为0.0078 - 0.25微克/毫升。在所有回顾和报告的患者中，当在加用利福平前后测定血清杀菌水平时，微生物学结果与临床结果之间存在正相关。因此，对于由金黄色葡萄球菌和表皮葡萄球菌引起的危及生命感染的特定患者，应考虑将利福平作为辅助治疗。
