Massanari R M, Donta S T
Chest. 1978 Mar;73(3):371-5. doi: 10.1378/chest.73.3.371.
Three patients with bacterial endocarditis (one case due to Staphylococcus aureus and two to S epidermidis) failed to improve on standard therapeutic regimens which were judged adequate by in vitro testing for sensitivity. Rifampin was added to the regimen in each case and resulted in increased bactericidal activity in the serum, sterilization of the cardiac valves, and clinical cure. The apparent clinical success that was achieved suggests that further investigation of the effectiveness of therapy with rifampin in selected cases of staphylococcal endocarditis is warranted.
三名患有细菌性心内膜炎的患者（1例由金黄色葡萄球菌引起，2例由表皮葡萄球菌引起），尽管采用了经体外药敏试验判定为足够的标准治疗方案，但病情仍未改善。在每种情况下，均在治疗方案中加入利福平，结果血清中的杀菌活性增强，心脏瓣膜菌血症消除，患者临床治愈。所取得的明显临床成功表明，有必要对利福平治疗某些葡萄球菌性心内膜炎病例的有效性进行进一步研究。
