Shmerling Zh G, Andreeva M V
Biokhimiia. 1978 Mar;43(3):424-32.
The activities of RNA-polymerases I and II in mouse liver nuclei isolated after injection of various poisons to mice were studied. An increased activity of RNA-polymerase I in the nuclei isolated from mouse liver after injection of the inhibitors of translation, i.e. cycloheximide and chlorotetracycline, was found. The activity of RNA-polymerase II remained unchanged. The inhibition of protein synthesis in mitochondria following the injection of chloramphenicol did not affect the activities of nuclear RNA-polymerases. The animal poisoning by carbon tetrachloride accompanied by a total decrease of the rates of protein and RNA synthesis in the liver decreased the activities of both RNA-polymerases, the activity of RNA-polymerase II being inhibited stronger as compared to that of RNA-polymerase I.
研究了给小鼠注射各种毒物后分离出的小鼠肝细胞核中RNA聚合酶I和II的活性。发现注射翻译抑制剂（即环己酰亚胺和金霉素）后从小鼠肝脏分离出的细胞核中RNA聚合酶I的活性增加。RNA聚合酶II的活性保持不变。注射氯霉素后线粒体中蛋白质合成的抑制并不影响核RNA聚合酶的活性。四氯化碳中毒的动物，其肝脏中蛋白质和RNA合成速率全面下降，这使得两种RNA聚合酶的活性均降低，与RNA聚合酶I相比，RNA聚合酶II的活性受到的抑制更强。
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