Serra M J, Ledford B E, Rankin J C, Baggett B
Biochim Biophys Acta. 1978 Nov 21;521(1):267-73. doi: 10.1016/0005-2787(78)90269-1.
The artificially stimulated decidual cell reaction has been used as a model to study changes occurring in the uterus at the time of implantation. Activities of RNA polymerases I, II and III were measured in uterine nuclei isolated from ovariectomized non-primed mice, hormonally primed mice, and hormonally primed mice following stimulation of the decidual cell reaction. Activities of all three RNA polymerases increased following hormonal priming of ovariectomized mice. In nuclei from stimulated uterine horns, activities of RNA polymerases I and III increased 9 h after stimulation of the decidual cell reaction and remained elevated through 21 h. RNA polymerase II activity did not change following stimulation of the decidual cell reaction. These changes in RNA polymerase activities occur at the time of increased histone modifications and may result from changes in the template capacity.
人工刺激的蜕膜细胞反应已被用作一种模型，以研究植入时子宫内发生的变化。在从卵巢切除未致敏小鼠、激素致敏小鼠以及刺激蜕膜细胞反应后的激素致敏小鼠中分离出的子宫细胞核中，测量了RNA聚合酶I、II和III的活性。在对卵巢切除小鼠进行激素致敏后，所有三种RNA聚合酶的活性均增加。在受刺激子宫角的细胞核中，RNA聚合酶I和III的活性在刺激蜕膜细胞反应后9小时增加，并在21小时内一直保持升高。刺激蜕膜细胞反应后，RNA聚合酶II的活性没有变化。RNA聚合酶活性的这些变化发生在组蛋白修饰增加的时候，可能是由模板能力的变化引起的。
