[可的松对大鼠肝细胞核中游离及结合的RNA聚合酶水平的影响]
[Effect of cortisone on free and bound RNA polymerase levels in rat liver cell nuclei].
作者信息
Konstantinova I M, Anok F, Vorob'ev V I
出版信息
Mol Biol (Mosk). 1981 Sep-Oct;15(5):1011-5.
Free and template-engaged RNA-polymerase activities were measured in nuclei from control and cortisone-stimulated rat livers. Both types of nuclei contain free and engaged alpha-amanitin sensitive (RNA-polymerase II) and insensitive (RNA-polymerase II) activities. In nuclei isolated after cortisone injection (1.5 and 3 hours) the stimulation of RNA-polymerase I in engaged form is observed. Unlike it, the higher activity of RNA-polymerase II in the free form is observed after cortisone induction, the activity of bound form being unchanged.
在对照大鼠和经可的松刺激的大鼠肝脏的细胞核中测量了游离的和与模板结合的RNA聚合酶活性。两种类型的细胞核均含有游离的和与模板结合的对α-鹅膏蕈碱敏感的（RNA聚合酶II）和不敏感的（RNA聚合酶I）活性。在注射可的松后（1.5小时和3小时）分离得到的细胞核中，观察到与模板结合形式的RNA聚合酶I受到刺激。与之不同的是，可的松诱导后观察到游离形式的RNA聚合酶II活性更高，而结合形式的活性未发生变化。
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