Bartl W, Spernol R, Breitenecker G
Geburtshilfe Frauenheilkd. 1984 May;44(5):295-9. doi: 10.1055/s-2008-1036661.
27 women with granulosa cell tumours of the ovaries were treated at the 2nd Gynaecological Department of the University of Vienna, Medical School, during 1962 to 1976. The principal symptoms were pain and irregular menstrual haemorrhages. Hysterectomy and bilateral salpingo-oophorectomy was performed in most cases. 8 patients were additionally irradiated. 25 women had lesions of stages I and II, whereas only 2 had stage III lesions. The overall survival rate was 90% after 5 years and 77% after 10 years. All 5 patients having polymorphic tumours with a high mitotic activity died of the disease. In 4 of these cases the tumour showed a sarcomatoid pattern. The high percentage of survival rate is partly due to the high percentage of stage I and II lesions and to the favourable prognosis of highly differentiated tumours. Granulosa cell tumours should always be treated via hysterectomy and bilateral salpingo-oophorectomy. Because of the poor prognosis of cases with polymorphic tumours and in cases with a high mitotic activity, simultaneous radiochemotherapy - as in ovarian cancer - may be considered.
