[外源性器官特异性RNA治疗大鼠硬化肝脏变化可逆性的超微结构和功能特征]
[Ultrastructural and functional features of the reversibility of sclerotic liver changes in rats treated with exogenous organ specific RNA].
作者信息
Vakulin G M, Marchenko V T, Prutovykh N N, Iakobson G S
出版信息
Biull Eksp Biol Med. 1978 Apr;85(4):495-501.
Ultrastructural peculiarities of hepatocytes and Kupffer's cells in rats during the spontaneous reversibility of the experimental cirrhosis of the liver under the usual conditions and also under the influence of exogenous RNA, administered by different methods, were studied. The changes in cell ultrastructure proved to correlate with those of the quantitative indices of the protein synthesizing the liver function during the hepatic cirrhosis reversibility. A positive role of the RNA influence of short duration on the intracellular reparative hepatocytes regeneration, and a negative one in case of RNA influence of long duration was revealed. Participation in the resorption of collagen both of the parenchymal cells and of the stroma was shown.
研究了在通常条件下以及在不同方法给予外源性RNA影响下，实验性肝硬化大鼠肝脏自发逆转过程中肝细胞和库普弗细胞的超微结构特点。结果表明，在肝硬化逆转过程中，细胞超微结构的变化与肝脏蛋白质合成功能定量指标的变化相关。揭示了短时间RNA影响对肝细胞内修复性再生具有积极作用，而长时间RNA影响则具有消极作用。研究还表明实质细胞和基质均参与了胶原蛋白的吸收过程。
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