[Ultrastructural changes in hepatocytes in the dynamics of the development of esperimental liver cirrhosis in rats].

Both hepatocyte necrosis and organ fibrosis and intracellular reparative regeneration of the injured cells took place in the posttoxic cirrhosis development. The outcome of cirrhosis is supposed to be determined by the prevalence of one of the processes--either the irreversible destruction, restoration or the hypertrophy of the parenchymal cells. The progress of cirrhosis evidently depended on the overstraining and progressive exhaustion of the intracellular compensatory adaptive mechanisms.