Metabolism of the proximate carcinogen 1'-hydroxysafrole and the isomer 3'-hydroxyisosafrole.

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作者信息

Peele J D, Oswald E O

出版信息

Bull Environ Contam Toxicol. 1978 Apr;19(4):396-402. doi: 10.1007/BF01685816.

DOI:10.1007/BF01685816

PMID:656641

Abstract

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本文引用的文献

Some 5-spirothiazolidiones.

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TOXIC PROPERTIES OF COMPOUNDS RELATED TO SAFROLE.

Toxicol Appl Pharmacol. 1965 Jan;7:18-24. doi: 10.1016/0041-008x(65)90069-4.

A COMPARISON OF THE TOXICITY OF SOME ALLYL, PROPENYL, AND PROPYL COMPOUNDS IN THE RAT.

Toxicol Appl Pharmacol. 1964 Jul;6:378-87. doi: 10.1016/s0041-008x(64)80002-8.

Identification of tertiary aminomethylenedioxypropiophenones as urinary metabolites of safrole in the rat and guinea pig.

Biochim Biophys Acta. 1971 Feb 23;230(2):237-47. doi: 10.1016/0304-4165(71)90208-x.

Chemical carcinogenesis: mechanisms and approaches to its control.

J Natl Cancer Inst. 1971 Sep;47(3):V-XIV.

The metabolism of the naturally occurring hepatocarcinogen safrole to 1'-hydroxysafrole and the electrophilic reactivity of 1'-acetoxysafrole.

Cancer Res. 1973 Mar;33(3):575-89.

1'-Hydroxysafrole, a proximate carcinogenic metabolite of safrole in the rat and mouse.

Cancer Res. 1973 Mar;33(3):590-600.

Hepatocarcinogenicity of estragole (1-allyl-4-methoxybenzene) and 1'-hydroxyestragole in the mouse and mutagenicity of 1'-acetoxyestragole in bacteria.

J Natl Cancer Inst. 1976 Dec;57(6):1323-31. doi: 10.1093/jnci/57.6.1323.

The metabolic activation of the carcinogen 1'-hydroxysafrole in vivo and in vitro and the electrophilic reactivities of possible ultimate carcinogens.

Cancer Res. 1976 May;36(5):1686-95.

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