Divac I
Ciba Found Symp. 1984;107:201-15.
The work described in this paper suggests that: (1) the neostriatum (a tier of the forebrain) is functionally heterogeneous, i.e. different neostriatal regions mediate responses in different situations; (2) regional specialization may be attributed to selective cortico-neostriatal connections, as indicated by anatomical and neurobehavioural evidence and studies with 2-deoxyglucose; (3) cortical areas and their corresponding principal neostriatal regions are organized 'in series'; (4) small lesions which cause severe but specific 'cognitive' effects do not induce movement disorders; (5) the transmitter of the cortico-neostriatal connections is glutamate. This work and other evidence suggests that the forebrain consists of systems that each contain a 'specific' thalamic nucleus and its associated cortical area and neostriatal region. This view, with three additional assumptions, can tentatively explain not only experimental neurobehavioural results but also certain symptoms of diseases involving the neostriatum.
（1）新纹状体（前脑的一层结构）在功能上具有异质性，即不同的新纹状体区域在不同情况下介导反应；（2）区域特化可能归因于选择性的皮质-新纹状体连接，解剖学、神经行为学证据以及2-脱氧葡萄糖研究均表明了这一点；（3）皮质区域及其相应的主要新纹状体区域是“串联”组织的；（4）导致严重但特定“认知”效应的小损伤不会诱发运动障碍；（5）皮质-新纹状体连接的神经递质是谷氨酸。这项研究及其他证据表明，前脑由多个系统组成，每个系统都包含一个“特定的”丘脑核及其相关的皮质区域和新纹状体区域。这种观点，再加上另外三个假设，不仅可以初步解释实验性神经行为学结果，还能解释涉及新纹状体疾病的某些症状。
