Drummond P D, Lance J W
Clin Exp Neurol. 1984;20:93-9.
The prevalence of icecream headache, icepick-like pains and premonitory symptoms (changes in mood, appetite and alertness one to 24 hours before headache onset) was studied in 530 patients referred for neurological assessment of headache. Pain in the head after icecream or cold drinks was reported by 37% of patients, more often by those whose headaches were associated with focal neurological symptoms and gastrointestinal disturbances. The affected region coincided with that of the customary headache in 33% of patients questioned. Icepick-like pains were reported by 39% of patients and were restricted to the distribution of the customary headache in 40% of these. Premonitory symptoms were noted by 30% of patients, particularly those with focal neurological symptoms before or during the attack. Premonitory symptoms may form part of a diffuse cerebral or hypothalamic disturbance preceding headache, while the prevalence of icecream headache and icepick-like pains suggests that pain pathways and neurovascular reflexes to sensory stimulation are hyperexcitable even between headache episodes. These phenomena favour a neurological origin of migrainous headache.
对530名因头痛接受神经学评估的患者进行了研究，以了解冰淇淋头痛、刺痛样疼痛和先兆症状（头痛发作前1至24小时情绪、食欲和警觉性的变化）的发生率。37%的患者报告在食用冰淇淋或冷饮后头部疼痛，与局灶性神经症状和胃肠道紊乱相关的头痛患者更为常见。在接受询问的患者中，33%的患者受影响区域与习惯性头痛区域一致。39%的患者报告有刺痛样疼痛，其中40%的患者疼痛局限于习惯性头痛的分布区域。30%的患者有先兆症状，尤其是在发作前或发作期间有局灶性神经症状的患者。先兆症状可能是头痛前弥漫性脑或下丘脑紊乱的一部分，而冰淇淋头痛和刺痛样疼痛的发生率表明，即使在头痛发作间期，疼痛通路和对感觉刺激的神经血管反射也过度兴奋。这些现象支持偏头痛的神经学起源。
