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白内障形成的分子基础。

The molecular basis of cataract formation.

作者信息

Benedek G B

出版信息

Ciba Found Symp. 1984;106:237-47. doi: 10.1002/9780470720875.ch14.

DOI:10.1002/9780470720875.ch14
PMID:6568976
Abstract

The theoretical and experimental basis for the transparency and opacification of the lens is reviewed. The microscopic mechanisms so far established which produce cataract are discussed. The use of quasielastic light scattering spectroscopy to measure in vivo the diffusivity of proteins and to sensitively detect the earliest stages of cataract formation is described.

摘要

本文综述了晶状体透明与混浊的理论和实验基础。讨论了目前已确定的导致白内障的微观机制。描述了使用准弹性光散射光谱法在体内测量蛋白质扩散率并灵敏检测白内障形成最早阶段的方法。

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The molecular basis of cataract formation.白内障形成的分子基础。
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2
Transparency and non-refractive functions of crystallins--a proposal.晶状体蛋白的透明度和非折射功能——一项提议。
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Quantitative detection of the molecular changes associated with early cataractogenesis in the living human lens using quasielastic light scattering.
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引用本文的文献

1
Determination of dideoxyosone precursors of AGEs in human lens proteins.测定人晶状体蛋白质中 AGEs 的二脱氧氧酮前体。
Arch Biochem Biophys. 2011 Oct;514(1-2):16-26. doi: 10.1016/j.abb.2011.07.012. Epub 2011 Jul 28.
2
Protein size resolution in human eye lenses by dynamic light scattering after in vivo measurements.体内测量后通过动态光散射对人眼晶状体进行蛋白质大小解析。
Graefes Arch Clin Exp Ophthalmol. 1998 Jan;236(1):18-23. doi: 10.1007/s004170050037.
3
Phase separation in aqueous solutions of lens gamma-crystallins: special role of gamma s.
晶状体γ-晶体蛋白水溶液中的相分离:γs的特殊作用。
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):377-82. doi: 10.1073/pnas.93.1.377.
4
Oxidation of gamma II-crystallin solutions yields dimers with a high phase separation temperature.γII-晶状体蛋白溶液的氧化会产生具有高相分离温度的二聚体。
Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1067-71. doi: 10.1073/pnas.92.4.1067.
5
Phase separation in lens cytoplasm is genetically linked to cataract formation in the Philly mouse.晶状体细胞质中的相分离与费城小鼠白内障的形成存在遗传关联。
Proc Natl Acad Sci U S A. 1987 Jan;84(1):122-5. doi: 10.1073/pnas.84.1.122.
6
Suppression of phase separation in solutions of bovine gamma IV-crystallin by polar modification of the sulfur-containing amino acids.通过含硫氨基酸的极性修饰抑制牛γIV-晶状体蛋白溶液中的相分离。
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4916-20. doi: 10.1073/pnas.88.11.4916.