成年大鼠视神经在沃勒变性过程中的神经胶质细胞

Neuroglia of the adult rat optic nerve in the course of wallerian degeneration.

作者信息

Shen C L, Liu K M

出版信息

Proc Natl Sci Counc Repub China B. 1984 Oct;8(4):324-34.

Abstract

The neurological reactions in Wallerian degeneration have been studied by electron microscopy in the optic nerve of adult albino rats from 7 to 120 days after unilateral enucleation. Reactive astrocytes contained abundant dense bodies, numerous microtubules and hyperplastic glial filaments. These astrocytes also assisted phagocytosis of degenerated myelin sheaths and in glial scar formation. Oligodendrocytes disconnected their cytoplasmic extensions, which were phagocytosed by microglial cells and astrocytes, by increased production of lysosomes. Microglial cells consisted of crinkled, long, rough endoplasmic reticula, several highly-active Golgi complexes, laminar inclusions and globoid lipid droplets. Microglia engulfed and lysed the disintegrated axons and myelin sheaths.

摘要

通过电子显微镜研究了成年白化大鼠单侧眼球摘除术后7至120天视神经中沃勒变性的神经学反应。反应性星形胶质细胞含有丰富的致密体、大量微管和增生的胶质丝。这些星形胶质细胞还协助吞噬变性的髓鞘并参与胶质瘢痕形成。少突胶质细胞断开其细胞质延伸部分，这些延伸部分通过增加溶酶体的产生而被小胶质细胞和星形胶质细胞吞噬。小胶质细胞由皱缩的、长的、粗糙的内质网、几个高活性的高尔基体复合体、层状内含物和球状脂滴组成。小胶质细胞吞噬并溶解崩解的轴突和髓鞘。