Pacciarini M A, Barbieri B, Colombo T, Broggini M, Garattini S, Donelli M G
Cancer Treat Rep. 1978 May;62(5):791-800.
Experimental studies on the distribution of adriamycin (AM) under different treatment conditions and possible correlations between tissue and plasma levels and chemotherapeutic activity are discussed. C57BL/6J mice bearing im Lewis lung carcinoma and (C3H x O2O)F1 mice bearing mammary carcinoma were injected iv with AM at a single dose of 15 mg/kg or with the same total amount of drug administered in spaced doses of 3.75 mg/kg for 4 consecutive days. In the two experimental systems studied, the drug reached approximately the same value in the tumor and spleen with both types of treatment, but with the 3.75-mg/kg x 4 schedule much lower AM concentrations were observed in the heart than with the single high-dose treatment. The therapeutic activity of the two treatments also differed: the antitumor and antimetastatic effect was the same in the two tumor systems, but with the 3.75-mg/kg x 4 schedule, increased survival and somewhat lower toxicity were observed. Daunorubicin, tested in the mammary carcinoma system with the two schedules of treatment, behaves very similarly to AM in terms of both distribution and chemotherapeutic effect.
本文讨论了阿霉素（AM）在不同治疗条件下的分布实验研究，以及组织和血浆水平与化疗活性之间可能存在的相关性。给患有Lewis肺癌的C57BL/6J小鼠和患有乳腺癌的（C3H×O2O）F1小鼠静脉注射AM，单次剂量为15mg/kg，或连续4天以3.75mg/kg的间隔剂量给予相同总量的药物。在研究的两个实验系统中，两种治疗方式下药物在肿瘤和脾脏中的浓度大致相同，但在3.75mg/kg×4的给药方案中，心脏中的AM浓度比单次高剂量治疗时低得多。两种治疗的疗效也有所不同：在两个肿瘤系统中，抗肿瘤和抗转移效果相同，但在3.75mg/kg×4的给药方案中，观察到生存期延长且毒性略低。在乳腺癌系统中用两种治疗方案测试的柔红霉素，在分布和化疗效果方面与AM非常相似。
