阿霉素体外细胞抑制作用对药物浓度和暴露时间的依赖性。
Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.
作者信息
Eichholtz-Wirth H
出版信息
Br J Cancer. 1980 Jun;41(6):886-91. doi: 10.1038/bjc.1980.165.
Abstract
The surviving fraction (SF) of Chinese hamster cells and HeLa cells after treatment with a range of Adriamycin concentrations and exposure times was determined. The cytostatic effect was proportional to the product of extracellular drug concentration (c) and exposure time (t) according to the equation: SF=e-ktc. By determining the intracellular drug concentration at various exposures, it could be shown that absorbed dose is not proportional to exposure dose.
摘要
测定了中国仓鼠细胞和HeLa细胞在一系列阿霉素浓度和暴露时间处理后的存活分数（SF）。根据公式：SF = e-ktc，细胞生长抑制作用与细胞外药物浓度（c）和暴露时间（t）的乘积成正比。通过测定不同暴露时间下的细胞内药物浓度，结果表明吸收剂量与暴露剂量不成正比。
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本文引用的文献
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