两个人类β-肌动蛋白相关加工基因的结构，其中一个位于一个简单重复序列旁边。
Structure of two human beta-actin-related processed genes one of which is located next to a simple repetitive sequence.
作者信息
Moos M, Gallwitz D
出版信息
EMBO J. 1983;2(5):757-61. doi: 10.1002/j.1460-2075.1983.tb01496.x.
Abstract
From a human gene library we have isolated and sequenced a beta-actin-like pseudogene, H beta Ac-psi 2, which lacks intervening sequences and contains several mutations resulting in frame-shifts, stop codons and in a departure from the known beta-actin protein sequence. We have also extended our sequence work on the intronless human beta-actin-related pseudogene H beta Ac-psi 1 described previously and we find that both genes are processed genes ending in a poly(dA) tract and flanked by direct repeats. The gene H beta Ac-psi 2 is preceded by a 230-bp region in which the simple sequence 5'-GAAA-3' is repeated greater than 40 times. This satellite-like sequence is highly repetitive in the human genome.
摘要
我们从一个人类基因文库中分离并测序了一个β-肌动蛋白样假基因HβAc-psi 2，它没有内含子序列，包含多个导致移码、终止密码子以及与已知β-肌动蛋白蛋白质序列不同的突变。我们还扩展了之前描述的无内含子人类β-肌动蛋白相关假基因HβAc-psi 1的序列研究，发现这两个基因都是加工基因，以聚（dA）尾结束并两侧有正向重复序列。基因HβAc-psi 2之前有一个230 bp的区域，其中简单序列5'-GAAA-3'重复超过40次。这种卫星样序列在人类基因组中高度重复。
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