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以色列放线菌在悉生大鼠中的口腔定植与致病性

Oral colonization and pathogenicity of Actinomyces israelii in gnotobiotic rats.

作者信息

Behbehani M J, Jordan H V, Heeley J D

出版信息

J Dent Res. 1983 Jan;62(1):69-74. doi: 10.1177/00220345830620011601.

DOI:10.1177/00220345830620011601
PMID:6571858
Abstract

Reference strains of A. israelii were orally implanted in germ-free rats after multiple inoculations. Early colonization was associated with areas of interdental hair and bedding impactions. Largest populations of organisms were isolated from teeth, as compared to the tongue, cheek, or palate. Examination of molar teeth with the scanning electron microscope revealed bacterial accumulations in the occlusal fissures, but not on smooth or approximal surfaces. Extensive plaque formation after 100-150 d was accompanied by root-surface caries and bacterial invasion of the pulp. There was no evidence of bacterial penetration of the dentin underlying surface enamel.

摘要

以色列放线菌参考菌株经多次接种后经口植入无菌大鼠体内。早期定植与齿间毛发和垫料嵌塞区域有关。与舌头、脸颊或上颚相比,从牙齿中分离出的生物体数量最多。用扫描电子显微镜检查臼齿发现,咬合裂隙中有细菌聚集,但光滑表面或邻面没有。100-150天后广泛的菌斑形成伴有根面龋和细菌侵入牙髓。没有证据表明细菌穿透了表面釉质下方的牙本质。

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Oral colonization and pathogenicity of Actinomyces israelii in gnotobiotic rats.以色列放线菌在悉生大鼠中的口腔定植与致病性
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引用本文的文献

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The Evolving Microbiome of Dental Caries.龋齿不断演变的微生物群落
Microorganisms. 2024 Jan 7;12(1):121. doi: 10.3390/microorganisms12010121.
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Infect Immun. 1985 Jan;47(1):301-5. doi: 10.1128/iai.47.1.301-305.1985.