局部和胃肠外免疫对粘性放线菌T6在大鼠体内定植的影响。
Effect of local and parenteral immunization on implantation of Actinomyces viscosus T6 in rats.
作者信息
Olsson J, Hsu S D, Kingman A, Cole M F
出版信息
Infect Immun. 1985 Jan;47(1):301-5. doi: 10.1128/iai.47.1.301-305.1985.
Abstract
Groups of rats immunized in the vicinity of the major salivary glands or immunized intraperitoneally with Actinomyces viscosus T6 and their sham-immunized controls were infected with the homologous bacterium. Significantly higher levels of salivary and serum antibody were induced by intraperitoneal than by salivary gland immunization. There were also significant inverse correlations between the levels of salivary and serum antibody and the levels of implantation of A. viscosus T6. The level of implantation of A. viscosus T6 was significantly lower in the immunized animals than in the controls. However, antibody had limited capacity to inhibit the establishment of this bacterium.
摘要
在主要唾液腺附近进行免疫或用粘性放线菌T6进行腹腔内免疫的大鼠组及其假免疫对照组，用同源细菌进行感染。与唾液腺免疫相比，腹腔内免疫诱导的唾液和血清抗体水平显著更高。唾液和血清抗体水平与粘性放线菌T6的定植水平之间也存在显著的负相关。免疫动物中粘性放线菌T6的定植水平显著低于对照组。然而，抗体抑制这种细菌定植的能力有限。
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