人2型腺病毒而非12型腺病毒在克隆的大鼠肝上皮细胞的次黄嘌呤磷酸核糖转移酶基因座处具有致突变性。
Human adenovirus type 2 but not adenovirus type 12 is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned rat liver epithelial cells.
作者信息
Paraskeva C, Roberts C, Biggs P, Gallimore P H
出版信息
J Virol. 1983 Apr;46(1):131-6. doi: 10.1128/JVI.46.1.131-136.1983.
Abstract
Using resistance to the base analog 8-azaguanine as a genetic marker, we showed that adenovirus type 2, but not adenovirus type 12, is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned diploid rat liver epithelial cells. Adenovirus type 2 increased the frequency of 8-azaguanine-resistant colonies by up to ninefold over the spontaneous frequency, depending on expression time and virus dose.
摘要
利用对碱基类似物8-氮杂鸟嘌呤的抗性作为遗传标记，我们发现，在克隆的二倍体大鼠肝上皮细胞的次黄嘌呤磷酸核糖转移酶基因座上，2型腺病毒具有致突变性，而12型腺病毒则没有。根据表达时间和病毒剂量的不同，2型腺病毒使8-氮杂鸟嘌呤抗性菌落的频率比自发频率提高了九倍之多。
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本文引用的文献
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