Baden E, Bouissou H
Oral Surg Oral Med Oral Pathol. 1983 Jan;55(1):34-46. doi: 10.1016/0030-4220(83)90303-1.
This histologic study of the periodontium of male white rats with chronic lathyrism demonstrates the appearance, progression, and persistence of certain pathologic changes caused by disordered collagen synthesis and maturation. Typical lesions were seen after 6 weeks. These include increased vascularity, especially in the periapical region, hyalinization and calcification of the transseptal fibers, alveolar bone and cementum resorption, interruption of the periodontal fibers with formation of typical hyaline zones surrounded by palisades of atypical fibroblasts, known as "lathyritic bodies," and an increase in mast cells.
对白化雄性大鼠慢性山黧豆中毒时牙周组织的组织学研究显示了由紊乱的胶原蛋白合成和成熟引起的某些病理变化的出现、进展和持续存在。6周后可见典型病变。这些病变包括血管增多，尤其是根尖周区域，牙间纤维透明化和钙化，牙槽骨和牙骨质吸收，牙周纤维中断并形成由非典型成纤维细胞栅栏围绕的典型透明区，即“山黧豆中毒小体”，以及肥大细胞增多。
