白三烯C4和前列腺素E2在大鼠体内的局部致水肿作用。

The local edemogenic effects of leukotriene C4 and prostaglandin E2 in rats.

作者信息

Gulati O P, Malmsten C, Ponard G, Gulati N

出版信息

Prostaglandins Leukot Med. 1983 Jan;10(1):11-7. doi: 10.1016/s0262-1746(83)80015-8.

Abstract

Leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) have been studied for their effects on vascular permeability in rats. LTC4 and/or PGE2 were dissolved in 0.3% ethanol and were administered subcutaneously (0.1 m1) in the plantar surface of one of the hind paws of different series of rats. The changes in vascular permeability were measured by the radioactive marker (HSA.I125) method. LTC4 administered in dose of 2 X 10(-8) M produced marked increase (77 and 133%) in the vascular permeability (local edemogenic effect). PGE2 administered in a dose of 10(-6) M also produced significant increase (38 and 40%) in the vascular permeability. However, PGE2 in the same dose either administered along with LTC4 or administered at 30 minutes after the injection of LTC4 (2 X 10(-8) M) did not have any potentiating effect on the edemogenic response of LTC4.

摘要

白三烯C4（LTC4）和前列腺素E2（PGE2）对大鼠血管通透性的影响已得到研究。LTC4和/或PGE2溶解于0.3%乙醇中，然后皮下注射（0.1 ml）到不同组大鼠的一只后爪足底表面。采用放射性标记物（人血清白蛋白I125）法测定血管通透性的变化。以2×10（-8）M的剂量给予LTC4可使血管通透性显著增加（分别增加77%和133%）（局部致水肿效应）。以10（-6）M的剂量给予PGE2也可使血管通透性显著增加（分别增加38%和40%）。然而，相同剂量的PGE2与LTC4一起给药，或在注射LTC4（2×10（-8）M）后30分钟给药，对LTC4的致水肿反应均无任何增强作用。