Gulati N, Philpot M E, Gulati O P, Malmsten C, Huggel H
Prostaglandins Leukot Med. 1983 Mar;10(3):257-68. doi: 10.1016/0262-1746(82)90081-6.
Leukotriene C4 (LTC4) and Prostaglandin E2 (PGE2) have been studied for their effects on the rat mesentery in vitro and in vivo. Their effects on the norepinephrine (NE) induced vasoconstrictions in the above vascular bed have also been investigated. LTC4 (10(-10)M) and PGE2 (2.8 X 10(-7)M) produced no direct effects on the perfusion pressure in the isolated perfused rat mesentery. However, LTC4 (10(-10)M) produced constriction of the arterioles in vivo. PGE2 (2.8 X 10(-7)M) did not produce any direct effect on the microcirculation. Indomethacin, when superfused for 10 min. in a concentration of 7 X 10(-5)M, produced significant arteriolar constriction; this effect was reversed when PGE2 was added to the superfusing media containing indomethacin. LTC4, perfused in a concentration of 10(-10)M, produced a time - dependent inhibitory effect on NE induced vasoconstrictions in vitro whereas PGE2 perfusions (2.8 X 10(-7)M) potentiated the NE responses. This potentiating effect of PGE2 was inhibited by indomethacin. In contrast, the topical application of PGE2 in vivo attenuated NE responses of the mesenteric arterioles.
白三烯C4（LTC4）和前列腺素E2（PGE2）已在体外和体内对大鼠肠系膜的作用方面进行了研究。它们对上述血管床中去甲肾上腺素（NE）诱导的血管收缩的影响也已得到研究。LTC4（10^-10 M）和PGE2（2.8×10^-7 M）对离体灌注大鼠肠系膜的灌注压力没有直接影响。然而，LTC4（10^-10 M）在体内可引起小动脉收缩。PGE2（2.8×10^-7 M）对微循环没有任何直接影响。吲哚美辛以7×10^-5 M的浓度 superfused 10分钟时，可引起明显的小动脉收缩；当将PGE2添加到含有吲哚美辛的 superfusing 介质中时，这种作用被逆转。以10^-10 M的浓度灌注的LTC4对体外NE诱导的血管收缩产生时间依赖性抑制作用，而PGE2灌注（2.8×10^-7 M）则增强了NE反应。PGE2的这种增强作用被吲哚美辛抑制。相比之下，在体内局部应用PGE2可减弱肠系膜小动脉的NE反应。 （注：文中superfused可能拼写有误，推测是superfused，可结合上下文进一步确认，暂按此翻译）
