Alevy Y G, Hutcheson P, Mueller K R, Slavin R G
J Reticuloendothel Soc. 1983 Jan;33(1):11-20.
The effect of uremic alveolar macrophages (AM phi) on the response of control nonadherent (NA) spleen cells to mitogens was examined. Alveolar macrophages purified from experimentally induced uremic rats were found to be significantly more suppressive than alveolar macrophages purified from control rats. When studying the characteristics of uremic AM phi, it was found that neither indomethacin nor anti-Ia antibody reverses their suppressive activity. In addition, uremic AM phi are shown to suppress via a suppressor factor released to the supernatant over an 18-hr incubation. The enhanced suppressive activity of uremic AM phi may have relevance to the severely suppressed cell-mediated immunity, the increased rate of infections, and the common presence of uremic pneumonitis in humans with chronic renal failure.
研究了尿毒症肺泡巨噬细胞（AM phi）对对照非黏附（NA）脾细胞对丝裂原反应的影响。从实验诱导的尿毒症大鼠中纯化的肺泡巨噬细胞比从对照大鼠中纯化的肺泡巨噬细胞具有更强的抑制作用。在研究尿毒症AM phi的特性时发现，吲哚美辛和抗Ia抗体均不能逆转其抑制活性。此外，尿毒症AM phi通过在18小时孵育期间释放到上清液中的抑制因子发挥抑制作用。尿毒症AM phi增强的抑制活性可能与慢性肾衰竭患者严重受抑的细胞介导免疫、感染率增加以及尿毒症肺炎的普遍存在有关。
