Gilboa N, Lum G M, Urizar R E
J Urol. 1983 Feb;129(2):364-7. doi: 10.1016/s0022-5347(17)52099-6.
Clinical manifestations of kidney disease, particularly renal failure, caused by malignant infiltration in patients with acute lymphoblastic leukemia or nonHodgkin's lymphoma have been described rarely. We report 1 case of acute lymphoblastic leukemia and 3 cases of nonHodgkin's lymphoma in which renal disease was the only or one of the presenting manifestations of malignancy. Of these patients 2 had rapidly progressive renal failure with nephromegaly, 1 presented with bilateral abdominal masses caused by severe nephromegaly and with microscopic hematuria, and 1 had microscopic hematuria without nephromegaly. In all 4 patients kidney biopsy revealed malignant infiltration. In the 2 patients who presented with renal failure kidney function promptly returned to normal after chemotherapy and irradiation of the kidneys. Prompt and correct diagnosis of nephropathy, when it is the only or one of the presenting signs of acute lymphoblastic leukemia or nonHodgkin's lymphoma, is necessary to expedite initiation of specific antitumor therapy.
急性淋巴细胞白血病或非霍奇金淋巴瘤患者因恶性浸润导致的肾脏疾病，尤其是肾衰竭的临床表现鲜有报道。我们报告了1例急性淋巴细胞白血病和3例非霍奇金淋巴瘤病例，其中肾脏疾病是恶性肿瘤唯一的或主要的临床表现之一。这些患者中，2例出现快速进展性肾衰竭并伴有肾肿大，1例表现为严重肾肿大引起的双侧腹部肿块及镜下血尿，1例有镜下血尿但无肾肿大。所有4例患者的肾脏活检均显示有恶性浸润。2例出现肾衰竭的患者在接受肾脏化疗和放疗后肾功能迅速恢复正常。当肾病是急性淋巴细胞白血病或非霍奇金淋巴瘤唯一的或主要的体征之一时，及时、正确的诊断对于加快启动特异性抗肿瘤治疗是必要的。
