Anderson C M, Pusztai L, Palmer J L, Cabanillas F, Ellerhorst J A
Department of Genitourinary Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, USA.
J Urol. 1998 Mar;159(3):714-7.
We recently observed nonHodgkin's lymphoma and renal cell carcinoma occurring simultaneously in several patients. We determine whether the incidence of co-occurrence of the 2 malignancies is greater than expected based on the incidence of each disease in the general population.
Patients diagnosed with simultaneous renal cell carcinoma and nonHodgkin's lymphoma were identified through the medical informatics data base at our cancer center. Charts of all patients were reviewed to collect detailed demographic information and confirm both diagnoses. United States population based cancer statistics (Surveillance, Epidemiology and End Results Program data) were used to arrive at the expected age adjusted incidence of co-occurrence of these diagnoses, and statistical analysis was performed to ascertain any differences between expected and observed incidences.
We identified 41 cases with both diagnoses between 1954 and 1995, including 21 diagnosed after 1987. The latter group was used for statistical analysis. The observed rates of renal cell carcinoma developing in the nonHodgkin's lymphoma population (1.86) and nonHodgkin's lymphoma developing in the renal cell carcinoma population (2.67) were greater than expected and both reached statistical significance.
There is a higher than expected incidence of co-occurrence of renal cell carcinoma and nonHodgkin's lymphoma. The cause remains speculative.
我们最近观察到数名患者同时发生非霍奇金淋巴瘤和肾细胞癌。我们要确定这两种恶性肿瘤同时出现的发生率是否高于基于一般人群中每种疾病发生率所预期的情况。
通过我们癌症中心的医学信息数据库识别出被诊断为同时患有肾细胞癌和非霍奇金淋巴瘤的患者。查阅所有患者的病历以收集详细的人口统计学信息并确认两种诊断。使用基于美国人群的癌症统计数据（监测、流行病学和最终结果计划数据）来得出这些诊断同时出现的预期年龄调整发病率，并进行统计分析以确定预期发病率与观察到的发病率之间是否存在差异。
我们在1954年至1995年期间识别出41例同时患有这两种疾病的病例，其中21例是在1987年之后确诊的。后一组用于统计分析。在非霍奇金淋巴瘤人群中发生肾细胞癌的观察率（1.86）以及在肾细胞癌人群中发生非霍奇金淋巴瘤的观察率（2.67）均高于预期，且两者均具有统计学意义。
肾细胞癌和非霍奇金淋巴瘤同时出现的发生率高于预期。其原因仍属推测。
