Aho K, Gordin A, Sievers K, Takala J
Acta Endocrinol Suppl (Copenh). 1983;251:11-5.
Familial occurrence of thyroid autoantibodies and elevated TSH levels was investigated among siblings from a middle-aged rural population in Finland. The initial sample consisted of 801 subjects representing 311 sibling groups. Paired sera taken at a five-year interval were available for testing from most of them. Thyroglobulin antibodies were detected in 26% of the siblings of probands with thyroglobulin antibodies, compared with 11% among siblings of probands who did not have these antibodies. The corresponding figures for thyroid microsomal antibodies were 32% and 11%, respectively. The frequency of positive test results among the siblings was about the same irrespective of the antibody titre of the proband. When the proband had only thyroid microsomal antibodies, most (66%) of the autoantibody-positive siblings were positive in this system only. When the proband had only thyroglobulin antibodies, the pattern among siblings was less clear. Nearly half of the cases with elevated TSH level but negative in the thyroid autoantibody tests were in families in which other members had evidence of thyroid autoimmunity. The findings are compatible with the concept that a few major genes affect susceptibility to thyroid autoimmune diseases.
在芬兰一个中年农村人口的兄弟姐妹中，对甲状腺自身抗体的家族性发生情况以及促甲状腺激素（TSH）水平升高进行了调查。初始样本包括代表311个兄弟姐妹组的801名受试者。大多数受试者都有间隔五年采集的配对血清可供检测。在患有甲状腺球蛋白抗体的先证者的兄弟姐妹中，26%检测到甲状腺球蛋白抗体，而在没有这些抗体的先证者的兄弟姐妹中这一比例为11%。甲状腺微粒体抗体的相应数字分别为32%和11%。无论先证者的抗体滴度如何，兄弟姐妹中阳性检测结果的频率大致相同。当先证者仅有甲状腺微粒体抗体时，大多数（66%）自身抗体阳性的兄弟姐妹仅在该系统中呈阳性。当先证者仅有甲状腺球蛋白抗体时，兄弟姐妹中的模式不太明确。在甲状腺自身抗体检测中促甲状腺激素水平升高但呈阴性的病例中，近一半来自其他成员有甲状腺自身免疫证据的家庭。这些发现与少数主要基因影响甲状腺自身免疫性疾病易感性的概念相符。
