Adam H K, Houghton H L, Yates R A, Young J, Donnelly R J
J Antimicrob Chemother. 1983 Jan;11 Suppl:193-9. doi: 10.1093/jac/11.suppl_a.193.
Cefotetan disodium has been given by zero order intravenous infusion at 75.8 mg/h to four healthy male volunteers over a 24-h period. Plasma concentrations rose until by 12 hs a mean steady state value of 37.5 mg/l was attained. In an additional four volunteers a loading dose of 0.5 g cefotetan was given immediately prior to a similar infusion. In these subjects concentrations in excess of the final steady-state value of 36.2 mg/l were achieved immediately and concentrations never fell below this value for the entire 24-h period of the study. The dose was well tolerated with the exception of an incidence of diarrhoea (2/8 mild and 1/8 severe). The pharmacokinetic findings are in good agreement with theoretical predictions based on single intravenous bolus doses of cefotetan and suggest that a loading dose, followed by an infusion would be suitable regime for cases of severe infection.
在24小时内，以75.8毫克/小时的速率对4名健康男性志愿者进行了头孢替坦二钠的零级静脉输注。血浆浓度不断上升，直至12小时时达到37.5毫克/升的平均稳态值。在另外4名志愿者中，在类似输注之前立即给予0.5克头孢替坦的负荷剂量。在这些受试者中，立即达到超过最终稳态值36.2毫克/升的浓度，并且在研究的整个24小时期间浓度从未低于该值。除腹泻发生率（2/8为轻度，1/8为重度）外，该剂量耐受性良好。药代动力学研究结果与基于头孢替坦单次静脉推注剂量的理论预测高度吻合，表明先给予负荷剂量再进行输注适用于严重感染病例。
