通过最低抑菌浓度（MIC）和纸片扩散法试验判断细菌病原体对头孢替坦的敏感性。

Susceptibility of bacterial pathogens to cefotetan judged by MIC and disc tests.

作者信息

Grimm H

出版信息

J Antimicrob Chemother. 1983 Jan;11 Suppl:37-43. doi: 10.1093/jac/11.suppl_a.37.

DOI:10.1093/jac/11.suppl_a.37

Abstract

The activity of cefotetan was tested against 683 bacterial strains by measuring the minimum inhibitory concentrations. Comparisons were made with cefoxitin, cefotaxime, moxalactam, cefoperazone and piperacillin. In addition, a regression line analysis was made with cefotetan discs (30 micrograms) using the ICS technique. Cefotetan was noted to have a broader spectrum of activity than cefoxitin and its antibacterial activity was comparable to that of cefotaxime and moxalactam. According to the regression line analysis a cefotetan inhibition zone diameter of greater than or equal 19 mm is interpreted as sensitive in agar diffusion tests.

摘要

通过测量最低抑菌浓度，对683株细菌菌株进行了头孢替坦活性测试。并与头孢西丁、头孢噻肟、拉氧头孢、头孢哌酮和哌拉西林进行了比较。此外，使用ICS技术对含30微克头孢替坦的药敏纸片进行了回归线分析。结果表明，头孢替坦的抗菌谱比头孢西丁更广，其抗菌活性与头孢噻肟和拉氧头孢相当。根据回归线分析，在琼脂扩散试验中，头孢替坦抑菌圈直径大于或等于19毫米被判定为敏感。