蛛网膜下腔出血对颅内前列腺素的影响。
Effects of subarachnoid haemorrhage on intracranial prostaglandins.
作者信息
Walker V, Pickard J D, Smythe P, Eastwood S, Perry S
出版信息
J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):119-25. doi: 10.1136/jnnp.46.2.119.
Abstract
Prostaglandins E2, F2 alpha, 6 oxo F1 alpha and thromboxane B2 increased in cisternal CSF following mock subarachnoid haemorrhage in dogs, particularly PGE2 (X25.5). Concentrations were increased also in lumbar CSF of five patients some 8 days after subarachnoid haemorrhage. Subarachnoid haemorrhage did not alter the production of prostaglandins by dog whole cortex or choroid plexuses in vitro, but production by pooled dissected cerebral arteries of PGE2 was increased and of 6 oxo F1 alpha was decreased. Intravenous indomethacin decreased prostaglandin production by cerebral tissues, and caused a marked decrease in the prostacyclin metabolite in CSF. The implications of our findings for the aetiology of cerebral vasospasm are discussed.
摘要
在犬类模拟蛛网膜下腔出血后，脑池脑脊液中前列腺素E2、F2α、6-氧代-F1α和血栓素B2增加，尤其是PGE2（增加了25.5倍）。在蛛网膜下腔出血约8天后，5例患者的腰段脑脊液中这些物质的浓度也升高。蛛网膜下腔出血并未改变犬类全脑皮质或脉络丛在体外产生前列腺素的情况，但分离的脑动脉汇集样本产生PGE2的量增加，而产生6-氧代-F1α的量减少。静脉注射吲哚美辛可降低脑组织产生前列腺素的量，并导致脑脊液中前列环素代谢物显著减少。本文讨论了我们的研究结果对脑血管痉挛病因学的意义。
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