蛛网膜下腔出血对颅内前列腺素的影响。
Effects of subarachnoid haemorrhage on intracranial prostaglandins.
作者信息
Walker V, Pickard J D, Smythe P, Eastwood S, Perry S
出版信息
J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):119-25. doi: 10.1136/jnnp.46.2.119.
Abstract
Prostaglandins E2, F2 alpha, 6 oxo F1 alpha and thromboxane B2 increased in cisternal CSF following mock subarachnoid haemorrhage in dogs, particularly PGE2 (X25.5). Concentrations were increased also in lumbar CSF of five patients some 8 days after subarachnoid haemorrhage. Subarachnoid haemorrhage did not alter the production of prostaglandins by dog whole cortex or choroid plexuses in vitro, but production by pooled dissected cerebral arteries of PGE2 was increased and of 6 oxo F1 alpha was decreased. Intravenous indomethacin decreased prostaglandin production by cerebral tissues, and caused a marked decrease in the prostacyclin metabolite in CSF. The implications of our findings for the aetiology of cerebral vasospasm are discussed.
摘要
在犬类模拟蛛网膜下腔出血后，脑池脑脊液中前列腺素E2、F2α、6-氧代-F1α和血栓素B2增加，尤其是PGE2（增加了25.5倍）。在蛛网膜下腔出血约8天后，5例患者的腰段脑脊液中这些物质的浓度也升高。蛛网膜下腔出血并未改变犬类全脑皮质或脉络丛在体外产生前列腺素的情况，但分离的脑动脉汇集样本产生PGE2的量增加，而产生6-氧代-F1α的量减少。静脉注射吲哚美辛可降低脑组织产生前列腺素的量，并导致脑脊液中前列环素代谢物显著减少。本文讨论了我们的研究结果对脑血管痉挛病因学的意义。
相似文献
1
Effects of subarachnoid haemorrhage on intracranial prostaglandins.蛛网膜下腔出血对颅内前列腺素的影响。
J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):119-25. doi: 10.1136/jnnp.46.2.119.
2
Measurement of prostaglandins in the cerebrospinal fluid in cat, dog, and man.猫、狗和人类脑脊液中前列腺素的测量。
J Neurochem. 1984 Dec;43(6):1642-9. doi: 10.1111/j.1471-4159.1984.tb06090.x.
3
Arterial eicosanoid production following chronic exposure to a periarterial haematoma.长期暴露于动脉周围血肿后动脉类花生酸的产生
J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):661-7. doi: 10.1136/jnnp.47.7.661.
4
[Effects of the subarachnoid hemorrhage on the release of arachidonate metabolites from canine cerebral arteries].
No To Shinkei. 1986 Dec;38(12):1137-42.
5
Effect of intraventricular haemorrhage and rebleeding following subarachnoid haemorrhage on CSF eicosanoids.蛛网膜下腔出血后脑室出血及再出血对脑脊液类花生酸的影响。
Acta Neurochir (Wien). 1994;129(3-4):152-7. doi: 10.1007/BF01406495.
6
Prevention of chronic cerebral vasospasm in dogs with ibuprofen and high-dose methylprednisolone.
Stroke. 1989 Aug;20(8):1021-6. doi: 10.1161/01.str.20.8.1021.
7
GC/MS analysis of prostaglandins in ventricular cerebrospinal fluid from head injured humans.
Prostaglandins Med. 1981 Aug;7(2):157-61. doi: 10.1016/0161-4630(81)90059-8.
8
Oral nimodipine reduces prostaglandin and thromboxane production by arteries chronically exposed to a periarterial haematoma and the antifibrinolytic agent tranexamic acid.口服尼莫地平可减少长期暴露于动脉周围血肿和抗纤溶药物氨甲环酸的动脉中前列腺素和血栓素的生成。
J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):727-31. doi: 10.1136/jnnp.50.6.727.
9
Cisternal and lumbar CSF levels of arachidonate metabolites after subarachnoid haemorrhage: an assessment of the biochemical hypothesis of vasospasm.蛛网膜下腔出血后脑池和腰段脑脊液中花生四烯酸代谢产物水平：对血管痉挛生化假说的评估
Acta Neurochir (Wien). 1987;84(3-4):129-35. doi: 10.1007/BF01418838.
10
Prostanoids and pial arteriolar diameter in hypotensive newborn pigs.
Am J Physiol. 1987 Apr;252(4 Pt 2):H687-91. doi: 10.1152/ajpheart.1987.252.4.H687.
引用本文的文献
1
Inflammatory Pathways Following Subarachnoid Hemorrhage.蛛网膜下腔出血后的炎症通路。
Cell Mol Neurobiol. 2020 Jul;40(5):675-693. doi: 10.1007/s10571-019-00767-4. Epub 2019 Dec 5.
2
Experimental basilar artery spasm caused by autologous blood application: effects of clot removal and topical nicardipine.
Acta Neurochir (Wien). 1993;121(1-2):72-5. doi: 10.1007/BF01405186.
3
Effect of intraventricular haemorrhage and rebleeding following subarachnoid haemorrhage on CSF eicosanoids.蛛网膜下腔出血后脑室出血及再出血对脑脊液类花生酸的影响。
Acta Neurochir (Wien). 1994;129(3-4):152-7. doi: 10.1007/BF01406495.
4
Arterial eicosanoid production following chronic exposure to a periarterial haematoma.长期暴露于动脉周围血肿后动脉类花生酸的产生
J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):661-7. doi: 10.1136/jnnp.47.7.661.
5
Production of prostaglandins and thromboxane by isolated cells from intracranial tumours.颅内肿瘤分离细胞产生前列腺素和血栓素
J Neurol Neurosurg Psychiatry. 1984 Jun;47(6):579-84. doi: 10.1136/jnnp.47.6.579.
6
Ultrastructure of cerebral arteries following experimental subarachnoid haemorrhage.实验性蛛网膜下腔出血后脑动脉的超微结构
J Neurol Neurosurg Psychiatry. 1985 Mar;48(3):256-62. doi: 10.1136/jnnp.48.3.256.
7
Oral nimodipine reduces prostaglandin and thromboxane production by arteries chronically exposed to a periarterial haematoma and the antifibrinolytic agent tranexamic acid.口服尼莫地平可减少长期暴露于动脉周围血肿和抗纤溶药物氨甲环酸的动脉中前列腺素和血栓素的生成。
J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):727-31. doi: 10.1136/jnnp.50.6.727.
8
Prostaglandin D2 monitoring in human CSF after subarachnoid hemorrhage: the possible role of prostaglandin D2 in the genesis of cerebral vasospasm.蛛网膜下腔出血后人体脑脊液中前列腺素D2的监测：前列腺素D2在脑血管痉挛发生中的可能作用
Ital J Neurol Sci. 1986 Feb;7(1):81-8. doi: 10.1007/BF02230422.
9
Effect of intracisternal thromboxane A2 analogue on cerebral artery permeability.脑池内血栓素A2类似物对脑动脉通透性的影响。
Acta Neurochir (Wien). 1988;90(3-4):144-51. doi: 10.1007/BF01560570.
10
Cisternal and lumbar CSF levels of arachidonate metabolites after subarachnoid haemorrhage: an assessment of the biochemical hypothesis of vasospasm.蛛网膜下腔出血后脑池和腰段脑脊液中花生四烯酸代谢产物水平：对血管痉挛生化假说的评估
Acta Neurochir (Wien). 1987;84(3-4):129-35. doi: 10.1007/BF01418838.
本文引用的文献
1
Facilitated transport of prostaglandins across the blood-cerebrospinal fluid and blood-brain barriers.前列腺素通过血脑屏障和血脑脊液屏障的易化转运。
J Physiol. 1976 Apr;256(2):273-85. doi: 10.1113/jphysiol.1976.sp011325.
2
Prediction of late ischemic complications after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood flow.通过术中测量脑血流量预测脑动脉瘤手术后的迟发性缺血性并发症
J Neurosurg. 1980 Sep;53(3):305-8. doi: 10.3171/jns.1980.53.3.0305.
3
Prostaglandin metabolism in experimental cerebral vasospasm.实验性脑血管痉挛中的前列腺素代谢
J Neurosurg. 1981 Nov;55(5):779-85. doi: 10.3171/jns.1981.55.5.0779.
4
Individual variations in response of human cerebral arterioles to vasoactive substances, human plasma, and CSF from patients with aneurysmal SAH.人脑小动脉对血管活性物质、人血浆和动脉瘤性蛛网膜下腔出血患者脑脊液反应的个体差异。
J Neurosurg. 1981 Sep;55(3):431-7. doi: 10.3171/jns.1981.55.3.0431.
5
Computed tomography in aneurysmal subarachnoid haemorrhage.动脉瘤性蛛网膜下腔出血的计算机断层扫描
J Neurol Neurosurg Psychiatry. 1980 Jun;43(6):522-4. doi: 10.1136/jnnp.43.6.522.
6
Biosynthesis of prostacyclin in rat cerebral microvessels and the choroid plexus.大鼠脑微血管和脉络丛中前列环素的生物合成。
J Neurochem. 1981 Mar;36(3):1192-201. doi: 10.1111/j.1471-4159.1981.tb01718.x.
7
Assay methods for prostaglandins and thromboxanes.前列腺素和血栓烷的检测方法。
Adv Prostaglandin Thromboxane Res. 1980;6:69-76.
8
Prostaglandins, macrophages, and immunity.前列腺素、巨噬细胞与免疫
J Immunol. 1980 Jul;125(1):1-5.
9
Prostaglandin profiles in tissue and blood vessels from human brain.人脑中组织和血管中的前列腺素谱。
J Neurochem. 1980 May;34(5):1331-3. doi: 10.1111/j.1471-4159.1980.tb09980.x.
10
Role of prostaglandins and arachidonic acid derivatives in the coupling of cerebral blood flow to cerebral metabolism.前列腺素和花生四烯酸衍生物在脑血流量与脑代谢耦合中的作用。
J Cereb Blood Flow Metab. 1981;1(4):361-84. doi: 10.1038/jcbfm.1981.41.
Zotero 插件