双嘧达莫对马血小板微粒体形成血栓素A2的影响。
The effects of dipyridamole on TXA2 formation by horse platelet microsomes.
作者信息
Katano Y, Imai S
出版信息
Prostaglandins Leukot Med. 1983 Feb;10(2):179-85. doi: 10.1016/s0262-1746(83)80008-0.
The effects of dipyridamole on thromboxane A2 formation by horse platelet microsomes were studied in comparison with those of imidazole, a prototype inhibitor of TXA2 synthetase and nifedipine, a calcium antagonistic vasodilator. Thromboxane A2 was synthesized by incubating PGH2 with horse platelet microsomes and was assayed on the superfused rabbit aorta. Dipyridamole induced as strong an inhibition of TXA2 synthesis as imidazole, while nifedipine was without effects. The possible beneficial clinical outcomes of this effect of dipyridamole are discussed.
将双嘧达莫对马血小板微粒体血栓素A2形成的影响与咪唑（血栓素A2合成酶的原型抑制剂）和硝苯地平（一种钙拮抗血管扩张剂）进行了比较研究。通过将PGH2与马血小板微粒体孵育来合成血栓素A2，并在灌注的兔主动脉上进行测定。双嘧达莫对血栓素A2合成的抑制作用与咪唑一样强，而硝苯地平则无作用。讨论了双嘧达莫这种作用可能的有益临床结果。
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