血栓素A2生成特异性抑制剂的测定
Determination of specific inhibitors of thromboxane A2 formation.
作者信息
Ladd N, Lewis G P
出版信息
Br J Pharmacol. 1980 May;69(1):3-5. doi: 10.1111/j.1476-5381.1980.tb10873.x.
Abstract
Activation of platelets by contact with collagen leads to the simultaneous formation of a prostaglandin and thromboxane (TXA2), which can be assayed biologically with the superfused rabbit aorta and rat stomach strip. By this method it has been shown that a cyclo-oxygenase inhibitor, aspirin, inhibited formation of both prostaglandin and TXA2 while a specific TXA2 synthetase inhibitor, clotrimazole, inhibited only TXA2 formation. The method is suitable as a primary screen in the search for TXA2 specific synthetase inhibitors.
摘要
血小板与胶原蛋白接触后被激活，会同时生成前列腺素和血栓素（TXA2），这两种物质可用灌注的兔主动脉和大鼠胃条进行生物学检测。通过这种方法已表明，环氧化酶抑制剂阿司匹林可抑制前列腺素和TXA2的生成，而特异性TXA2合成酶抑制剂克霉唑仅抑制TXA2的生成。该方法适合作为寻找TXA2特异性合成酶抑制剂的初步筛选方法。
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