Brune D, Gjerdet N, Paulsen G
Scand J Dent Res. 1983 Feb;91(1):66-71. doi: 10.1111/j.1600-0722.1983.tb00778.x.
Particles of a conventional lathe-cut, a spherical non-gamma 2 and a copper amalgam have been gastrointestinally administered to rats for the purpose of evaluation of the dissolution resistance. The animals were sacrificed after 20 hrs. The contents of copper, cadmium, indium, mercury and zinc in kidney, liver, lung or blood were measured using nuclear tracer techniques. From a copper amalgam an extreme release of copper was demonstrated. This study stimulates the clinical condition of elemental release from swallowed amalgam particles after amalgam insertion or after removal of old amalgam fillings. Specimens of the same types of amalgams were also exposed to artificial saliva for a period of 10 days. The amounts of copper and mercury released were measured with flame and flameless atomic absorption spectrophotometry respectively. The levels of copper and mercury released from the copper amalgam were approximately 50 times those of the two other amalgam types studied.
为评估耐溶解性能，已将传统车削切割的颗粒、球形非γ2颗粒和铜汞合金经胃肠道给予大鼠。20小时后处死动物。使用核示踪技术测量肾脏、肝脏、肺或血液中铜、镉、铟、汞和锌的含量。结果表明，铜汞合金会极度释放铜。本研究引发了对汞合金植入后或去除旧汞合金填充物后吞咽的汞合金颗粒中元素释放的临床状况的探讨。同样类型的汞合金标本也暴露于人工唾液中10天。分别用火焰原子吸收分光光度法和无火焰原子吸收分光光度法测量释放的铜和汞的量。从铜汞合金中释放的铜和汞的水平约为所研究的其他两种汞合金类型的50倍。
