银屑病、银屑病关节炎和强直性脊柱炎中的组织相容性抗原。
Histocompatibility antigens in psoriasis, psoriatic arthropathy, and ankylosing spondylitis.
作者信息
Armstrong R D, Panayi G S, Welsh K I
出版信息
Ann Rheum Dis. 1983 Apr;42(2):142-6. doi: 10.1136/ard.42.2.142.
Abstract
Patients with ankylosing spondylitis, psoriatic arthritis, and psoriasis alone were typed for HLA A, B, Cw, and DR antigens, and the antigen frequencies were compared with those in a normal control population and in patients with rheumatoid arthritis. Patients with psoriasis had a significantly raised frequency of Cw6. Those with arthritis in addition to their psoriasis also had raised frequencies of B27 and DR7. Patients with ankylosing spondylitis were characterised by the expected high frequency of HLA B27. Again, those with peripheral arthritis had a higher B27 and DR7 frequency than those without. DR3 is associated with the development of erosions in psoriatic arthritis.
摘要
仅对患有强直性脊柱炎、银屑病关节炎和银屑病的患者进行 HLA A、B、Cw 和 DR 抗原分型，并将抗原频率与正常对照人群以及类风湿性关节炎患者的抗原频率进行比较。银屑病患者的 Cw6 频率显著升高。除银屑病外还患有关节炎的患者，其 B27 和 DR7 频率也升高。强直性脊柱炎患者的特征是 HLA B27 频率预期较高。同样，患有外周关节炎的患者比未患外周关节炎的患者 B27 和 DR7 频率更高。DR3 与银屑病关节炎中糜烂的发生有关。
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