Kantor S M, Hsu S H, Bias W B, Arnett F C
Clin Exp Rheumatol. 1984 Apr-Jun;2(2):105-9.
Relationships between clinical features of psoriatic arthritis and HLA antigens were examined in 60 patients. HLA-B locus antigens, Bw38, B17, B27 and possibly Bw39 were significantly increased, while HLA-D and DR specificities were not. Cw6 was not studied. The relative risk for disease was doubled in patients having B27 plus a psoriatic HLA antigen. HLA-Bw38 correlated with young age of onset for psoriasis and arthritis, asymmetrical peripheral involvement, and, along with B27, combined peripheral/axial disease. While B17 was also associated with young onset psoriasis, arthritis onset was later and symmetrical in pattern. Certain clinical subsets of psoriatic arthritis may relate to HLA status, and disease susceptibility appears to lie closer to HLA-B than to HLA-D.
对60例银屑病关节炎患者的临床特征与HLA抗原之间的关系进行了研究。HLA - B位点抗原Bw38、B17、B27以及可能的Bw39显著增加，而HLA - D和DR特异性则未增加。未对Cw6进行研究。携带B27加银屑病性HLA抗原的患者患该病的相对风险增加一倍。HLA - Bw38与银屑病和关节炎的早发年龄、不对称的外周受累相关，并且与B27一起，与外周/中轴联合疾病相关。虽然B17也与早发性银屑病相关，但关节炎发病较晚且呈对称性。银屑病关节炎的某些临床亚组可能与HLA状态有关，并且疾病易感性似乎更接近HLA - B而非HLA - D。
