Carlin R K, Siekevitz P
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3517-21. doi: 10.1073/pnas.80.11.3517.
Changes in the proportion of synapses containing postsynaptic densities with perforations during periods of increased synapse formation have led us to propose a hypothesis describing a possible division of preexisting synapses. Relevant features of this model are that various types of stimulation result in the following sequence of events: (i) the synaptic junction increases in area; (ii) a perforation forms in the enlarging synaptic junction; (iii) a synaptic spinule appears apposed to the perforation in the postsynaptic density; (iv) the perforation in the synaptic junction increases in size until the synaptic junction splits into two separate synaptic junctions within the same synaptic terminal; and (v) the dendritic spine divides into two, each containing a synaptic junction. Physiological responses in which synapse division may possibly play a role include hormone-induced neuronal changes, reinnervation of dendrites after lesions, and learning and memory.
在突触形成增加的时期，含有带穿孔的突触后致密物的突触比例的变化，促使我们提出一个假说，该假说描述了一种对已存在突触可能的划分方式。该模型的相关特征是，各种类型的刺激会导致以下一系列事件：（i）突触连接面积增加；（ii）在扩大的突触连接中形成一个穿孔；（iii）一个突触小棘出现在突触后致密物中与穿孔相对的位置；（iv）突触连接中的穿孔尺寸增大，直到突触连接在同一突触终末内分裂成两个独立的突触连接；以及（v）树突棘分成两个，每个都包含一个突触连接。突触分裂可能起作用的生理反应包括激素诱导的神经元变化、损伤后树突的重新支配以及学习和记忆。
