Maier V, Scheich H
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3860-4. doi: 10.1073/pnas.80.12.3860.
This report describes experiments in which successful acoustic imprinting correlates with differential uptake of D-2-deoxy[14C]glucose in particular forebrain areas that are not considered primarily auditory. Newly hatched guinea chicks (Numida meleagris meleagris) were imprinted by playing 1.8-kHz or 2.5-kHz tone bursts for prolonged periods. Those chicks were considered to be imprinted who approached the imprinting stimulus (emitted from a loudspeaker) and preferred it over a new stimulus in a simultaneous discrimination test. In the 2-deoxy-D-glucose experiment all chicks, imprinted and naive, were exposed to 1.8-kHz tone bursts for 1 hr. As shown by the autoradiographic analysis of the brains, neurons in the 1.8-kHz isofrequency plane of the auditory "cortex" (field L) were activated in all chicks, whether imprinted or not. However, in the most rostral forebrain striking differences were found. Imprinted chicks showed an increased 2-deoxy-D-glucose uptake in three areas, as compared to naive chicks: (i) the lateral neostriatum and hyperstriatum ventrale, (ii) a medial magnocellular field (medial neostriatum/hyperstriatum ventrale), and (iii) the most dorsal layers of the hyperstriatum. Based on these findings we conclude that these areas are involved in the processing of auditory stimuli once they have become meaningful by experience.
本报告描述了一些实验，其中成功的声学印记与D-2-脱氧[14C]葡萄糖在特定前脑区域的差异性摄取相关，这些区域并非主要被视为听觉区域。刚孵出的珠鸡（Numida meleagris meleagris）通过长时间播放1.8千赫或2.5千赫的短音爆来进行印记。那些在同时进行的辨别测试中接近印记刺激（从扬声器发出）并比新刺激更偏好它的小鸡被认为是被印记了。在2-脱氧-D-葡萄糖实验中，所有小鸡，无论是被印记的还是未被印记的，都暴露于1.8千赫的短音爆1小时。正如大脑的放射自显影分析所示，所有小鸡，无论是否被印记，听觉“皮层”（L区）的1.8千赫等频率平面中的神经元都被激活。然而，在前脑最前端发现了显著差异。与未被印记的小鸡相比，被印记的小鸡在三个区域显示出2-脱氧-D-葡萄糖摄取增加：（i）外侧新纹状体和腹侧上纹状体，（ii）一个内侧大细胞区（内侧新纹状体/腹侧上纹状体），以及（iii）上纹状体最背侧层。基于这些发现，我们得出结论，一旦听觉刺激通过经验变得有意义，这些区域就参与了其处理过程。
