早产儿血浆前列腺素E2和F2α：与呼吸窘迫综合征和动脉导管未闭的关联。

Plasma prostaglandin E2 and F2 alpha in preterm infants: association with respiratory distress syndrome and patent ductus arteriosus.

作者信息

Kopelman A E, Dombroski D, Engelke S C, Louis T M

出版信息

Prostaglandins Leukot Med. 1983 Apr;10(4):423-31. doi: 10.1016/0262-1746(83)90054-9.

Abstract

In order to determine if prostaglandin values correlate with gestational age, birth weight, postnatal age, or respiratory distress syndrome (RDS), we determined plasma prostaglandin F2 alpha (PGF2 alpha) and prostaglandin E2 (PGE2) by specific radioimmunoassay in 34 samples from 27 preterm infants. Neither prostaglandin correlated with gestational age or with birth weight. PGF2 alpha decreased (p less than 0.3) with postnatal age. Values for PGF2 alpha and PGE2 in each sample varied together (p less than .01) but only PGF2 alpha increased (p less than .09) in infants with RDS. The highest PGF2 alpha values occurred in infants with severe RDS, including four infants with patent ductus arteriosus (PDA). In contrast, plasma PGE2 was not elevated in infants with RDS or PDA.

摘要

为了确定前列腺素值是否与胎龄、出生体重、出生后年龄或呼吸窘迫综合征（RDS）相关，我们采用特异性放射免疫分析法测定了27例早产儿34份样本中的血浆前列腺素F2α（PGF2α）和前列腺素E2（PGE2）。两种前列腺素均与胎龄或出生体重无关。PGF2α随出生后年龄降低（p<0.3）。每个样本中PGF2α和PGE2的值共同变化（p<0.01），但只有PGF2α在患有RDS的婴儿中升高（p<0.09）。最高的PGF2α值出现在患有严重RDS的婴儿中，包括4例患有动脉导管未闭（PDA）的婴儿。相比之下，患有RDS或PDA的婴儿血浆PGE2并未升高。