Seppă L, Hausen H, Tuutti H, Luoma H
Scand J Dent Res. 1983 Apr;91(2):96-8. doi: 10.1111/j.1600-0722.1983.tb00783.x.
Effect of applications of a sodium fluoride varnish, Duraphat, on progress of initial caries lesions was studied in 11-13-year-old children. All 60 children included in the study had high caries activity and life-long exposure to fluoridated drinking water. The varnish was applied semiannually using the half mouth technique, and annual clinical and radiographic examinations were made for 3 years. The treatment had little effect on the progress of initial caries lesions present before the first application of varnish. The progress of caries lesions formed during the study was inhibited more distinctly, and the difference between test and control side in the rate of progress of caries lesions was highly statically significant. Use of fluoride varnish seems to help prevent further development of early caries lesions.
在11至13岁儿童中研究了应用氟化钠涂剂Duraphat对初期龋损进展的影响。该研究纳入的所有60名儿童均有高龋活性且长期饮用含氟饮用水。采用半口技术每半年应用一次涂剂，并进行为期3年的年度临床和影像学检查。该治疗对首次应用涂剂前已存在的初期龋损进展影响甚微。在研究期间形成的龋损进展受到更明显的抑制，并且试验侧和对照侧龋损进展速率之间的差异具有高度统计学意义。使用氟化钠涂剂似乎有助于预防早期龋损的进一步发展。
