Seppä L, Tuutti H, Luoma H
Scand J Dent Res. 1981 Apr;89(2):143-8. doi: 10.1111/j.1600-0722.1981.tb01664.x.
The benefit of semi-annual applications of sodium fluoride varnish (Duraphat) and silane fluoride varnish (Fluor Protector) was studied in 11-13 year-old children with life-long exposure to fluoridated drinking water (1-1.2 parts/10(6)). Annual clinical and radiographic examinations were made on 67 children in the Duraphat group and 71 children in the Fluor Protector group. Fluoride varnish was applied semi-annually using the half-mouth technique. At the end of 2 years, the mean overall DMFS-increments on the control side and test side of the Duraphat group were 5.0 and 3.8 (p less than 0.01), respectively, and of the Fluor Protector group 3.7 and 3.3 (NS). The caries reductions were 24% and 12%, respectively. Since there were no differences between initial mean DMFS scores of the groups, it was assumed that lower increments in the Fluor Protector group were due to Fluoride ions crossing the midline and providing protection on the control side as well. When increments in the Duraphat control side and the Fluor Protector test side were compared, the caries reduction of Fluor Protector was 35% (p less than 0.01). Fluoride varnishes provide additional benefit even when fluoride intake from drinking water is optimal.
在长期饮用含氟饮用水（1 - 1.2 ppm）的11 - 13岁儿童中，研究了每半年应用一次氟化钠漆（Duraphat）和硅烷氟化物漆（Fluor Protector）的益处。对Duraphat组的67名儿童和Fluor Protector组的71名儿童进行了年度临床和影像学检查。采用半口技术每半年涂抹一次氟化物漆。2年后，Duraphat组对照侧和试验侧的平均总DMFS增量分别为5.0和3.8（p < 0.01），Fluor Protector组分别为3.7和3.3（无显著性差异）。龋病减少率分别为24%和12%。由于各组初始平均DMFS评分无差异，推测Fluor Protector组增量较低是由于氟离子穿过中线并在对照侧也提供了保护。当比较Duraphat组对照侧和Fluor Protector组试验侧的增量时，Fluor Protector组的龋病减少率为35%（p < 0.01）。即使饮用水中的氟摄入量处于最佳水平，氟化物漆仍能提供额外的益处。
