Darbyshire P J, Eden O B
Cancer Genet Cytogenet. 1983 Jul;9(3):233-8. doi: 10.1016/0165-4608(83)90006-7.
A case is reported of an 11-year-old girl with Ph1-positive chronic granulocytic leukemia. Very early in her illness the original 46,XX,t(9:22) cell population in the marrow became replaced by a second abnormal cell line, 45,XX,-7. This hypodiploid clone then remained dominant in the marrow until her death from myeloid blast crisis over 3 years later. It is suggested that the 45,XX,-7 cell line may have been induced by chemotherapy, and this possibility is discussed with particular reference to similar changes seen in secondary ANLL following treatment for lymphomas and other hematological malignancies.
报告了一例11岁Ph1阳性慢性粒细胞白血病女孩的病例。在她患病早期，骨髓中最初的46,XX,t(9:22)细胞群就被第二种异常细胞系45,XX,-7所取代。这种亚二倍体克隆随后在骨髓中一直占主导地位，直到3年多后她死于髓系原始细胞危象。有人提出，45,XX,-7细胞系可能是由化疗诱导产生的，并特别参照淋巴瘤和其他血液系统恶性肿瘤治疗后继发性急性非淋巴细胞白血病中出现的类似变化对这种可能性进行了讨论。
