Shabtai F, Klar D, Schwartz A, Moroz A, Halbrecht I
Cancer Genet Cytogenet. 1983 Jul;9(3):281-7. doi: 10.1016/0165-4608(83)90012-2.
Two young sisters presenting with malignant or premalignant conditions inherited two marker chromosomes (a 13p- and a 16 with a fragile site at q22). Malignancy was reported in the family on both the mother's and father's side. According to data from the literature on similar markers and from our personal observations, a possible significance may be suggested for these markers. Search for markers must be encouraged in families with high incidence of cancer. Eventually, we may find markers which will help in understanding the processes of carcinogenesis and possibly indicate individuals at risk.
两名患有恶性或癌前病变的年轻姐妹遗传了两条标记染色体（一条13号染色体短臂缺失和一条16号染色体，在q22处有一个脆性位点）。据报道，父母双方的家族中都有恶性肿瘤病例。根据文献中关于类似标记物的数据以及我们的个人观察结果，这些标记物可能具有一定意义。对于癌症高发家族，必须鼓励寻找标记物。最终，我们可能会找到有助于理解致癌过程并可能指示高危个体的标记物。
