Blair A, Grauman D J, Lubin J H, Fraumeni J F
J Natl Cancer Inst. 1983 Jul;71(1):31-7.
The mortality experience of a cohort of 3,827 white men licensed to apply pesticides in Florida was evaluated to investigate health effects associated with chronic exposure to pesticides. Although the overall standardized mortality ratio (SMR) for these structural pest control workers was not significantly elevated (SMR = 103), excess deaths were observed for leukemia, particularly acute myeloid leukemia (3 observed vs. 0.9 expected), and cancers of the brain (SMR = 200) and lung (SMR = 135). The risk of lung cancer rose with the number of years licensed with SMR of 101, 155, and 289 among those licensed for less than 10 years, for 10-19 years, and for 20 years or more, respectively. Ratios of directly adjusted rates showed similar patterns with observed-to-expected ratios of 100, 175, and 186 for the length of licensure categories. Mortality from lung cancer was greater among persons first licensed before age 40 (SMR = 234) than among those first licensed after age 40 (SMR = 115). Although information on tobacco use was not available, the increasing risk of lung cancer with number of years licensed and the capacity of certain pesticides to produce neoplasms in laboratory animals suggested that some pesticides may be carcinogenic in humans.
对佛罗里达州3827名有农药施用许可的白人男性队列的死亡情况进行了评估，以调查与长期接触农药相关的健康影响。尽管这些从事结构害虫防治工作的人员的总体标准化死亡比（SMR）没有显著升高（SMR = 103），但观察到白血病尤其是急性髓细胞白血病（观察到3例，预期0.9例）、脑癌（SMR = 200）和肺癌（SMR = 135）存在超额死亡情况。肺癌风险随着持许可年限增加而上升，持许可年限不足10年、10 - 19年和20年及以上者的SMR分别为101、155和289。直接调整率的比值显示出类似模式，不同持许可年限类别的观察值与预期值之比分别为100、175和186。40岁之前首次获得许可者的肺癌死亡率（SMR = 234）高于40岁之后首次获得许可者（SMR = 115）。尽管没有关于烟草使用的信息，但肺癌风险随持许可年限增加以及某些农药在实验动物中诱发肿瘤的能力表明，某些农药可能对人类具有致癌性。
