Moulin J J, Lafontaine M, Mantout B, Belanger A, Michel M, Wild P, Clavel T, Fournier M, Fontana J M
Institut National de Recherche et de Sécurité, Service d'Epidémiologie, Vandoeuvre.
Rev Epidemiol Sante Publique. 1995;43(2):107-21.
A mortality study was carried out in two factories producing stainless steel in order to assess lung cancer risk among workers employed in coke oven, blast and open hearth furnaces, foundry, electric furnace, hot and cold rolling mills and pickling areas. Occupational exposures of interest were chromium compounds, nickel compounds, polycyclic aromatic hydrocarbons (PAH), silica and asbestos. All male workers having at least one year of employment between 01.01.1960 and 31.12.1990 were followed up for mortality. The vital status was assessed from birth place registries. Complete job histories since date of first employment were abstracted from the company files. The smoking habits of 50% of the cohort members were known from medical records. The observed number of deaths (obs) were compared with the expected ones based on regional rates with adjustment for age, sex and calendar time (Standardized Mortality Ratio, SMR). The cohorts included 6324 (factory 1) and 5270 (factory 2) workers. The overall mortality did not differ markedly from that expected in both factories: SMR = 0.95 (obs = 1540, p = 0.05) in factory 1 and SMR = 1.06 (obs = 916, non-significant) in factory 2. SMRs for lung cancer did not differ from unity, respectively 0.99 (obs = 105) and 1.00 (obs = 54), in whole cohorts. Non-significant lung cancer excesses were observed among workers of some workshops where exposures of interest might have occurred: coke oven (SMR = 2.04), blast furnace (SMR = 1.36), open hearth furnace (SMR = 1.75), hot rolling mills (SMR = 1.29). These processes, however, are no longer involved in the study factories. Furthermore, no lung cancer excess was observed among workers employed in current workshops: electric furnaces and cold rolling mills.
为评估焦炉、鼓风炉、平炉、铸造厂、电炉、热轧和冷轧厂以及酸洗区工人的肺癌风险，在两家生产不锈钢的工厂开展了一项死亡率研究。研究关注的职业暴露因素包括铬化合物、镍化合物、多环芳烃（PAH）、二氧化硅和石棉。对1960年1月1日至1990年12月31日期间至少工作一年的所有男性工人进行了死亡率随访。生命状况从出生地登记处进行评估。自首次就业之日起的完整工作经历从公司档案中提取。50%队列成员的吸烟习惯可从医疗记录中得知。将观察到的死亡人数（obs）与基于地区死亡率并根据年龄、性别和日历时间调整后的预期死亡人数进行比较（标准化死亡率，SMR）。队列包括6324名（工厂1）和5270名（工厂2）工人。两家工厂的总体死亡率与预期死亡率无明显差异：工厂1的SMR = 0.95（obs = 1540，p = 0.05），工厂2的SMR = 1.06（obs = 916，无显著性差异）。整个队列中肺癌的SMR与1无差异，分别为0.99（obs = 105）和1.00（obs = 54）。在一些可能发生相关职业暴露的车间工人中观察到非显著性的肺癌超额：焦炉（SMR = 2.04）、鼓风炉（SMR = 1.36）、平炉（SMR = 1.75）、热轧厂（SMR = 1.29）。然而，这些工艺在研究工厂中已不再使用。此外，在当前车间（电炉和冷轧厂）工作的工人中未观察到肺癌超额。
