Luo X M, Wei H J, Yang S P
J Natl Cancer Inst. 1983 Jul;71(1):75-80.
Male weanling inbred SD rats were given ad libitum a nutritionally adequate semipurified diet and demineralized drinking water without or with 100 or 200 ppm tungsten (W) or 2 or 20 ppm molybdenum (Mo) added to the drinking water. The animals were gastrically intubated with a solution of N-nitrososarcosine ethyl ester (NSEE) from the 4th week twice weekly for 2-8 consecutive weeks. The addition of Mo at either the 2- or 20-ppm level significantly inhibited NSEE-induced esophageal and forestomach carcinogenesis. The 200 ppm W significantly countered the inhibitory effect of a low level of Mo naturally occurring in the diet.
雄性断奶近交系SD大鼠随意进食营养充足的半纯化日粮，并饮用去离子水，去离子水中不添加或添加100 ppm或200 ppm的钨（W），或添加2 ppm或20 ppm的钼（Mo）。从第4周开始，每周两次给动物经胃插管灌入N-亚硝基肌氨酸乙酯（NSEE）溶液，连续灌胃2至8周。添加2 ppm或20 ppm水平的钼可显著抑制NSEE诱导的食管癌和前胃癌发生。200 ppm的钨可显著对抗日粮中天然存在的低水平钼的抑制作用。
