Elzay R P
Oral Surg Oral Med Oral Pathol. 1983 May;55(5):497-506. doi: 10.1016/0030-4220(83)90236-0.
A review of the English literature revealed ten lesions classified as Riga-Fede's disease and nineteen lesions classified as traumatic eosinophilic granuloma. These two entities have the same histologic features and are often associated with a history of trauma. These are benign, reactive, nonosseous lesions that occur either in infancy or later in life. It is suggested that they be considered as one entity. To delineate them from more aggressive lesions, such as the eosinophilic granuloma of histiocytosis X, the author suggests the term traumatic ulcerative granuloma with stromal eosinophilia. Forty-one previously unreported cases are described. Histologic examination revealed the presence of mast cells in addition to eosinophils. A pathogenesis for traumatic ulcerative granuloma with stromal eosinophilia, based on the hypothesis that mast cells release an eosinophilic chemotactic factor and that eosinophils may act as cytotoxic agents, is suggested.
对英文文献的回顾显示，有10例病变被归类为里加-费德氏病，19例病变被归类为创伤性嗜酸性肉芽肿。这两种病变具有相同的组织学特征，且常与创伤史相关。它们是发生于婴儿期或生命后期的良性、反应性、非骨性病变。建议将它们视为同一实体。为了将它们与更具侵袭性的病变（如组织细胞增多症X的嗜酸性肉芽肿）区分开来，作者建议使用“伴有间质嗜酸性粒细胞增多的创伤性溃疡性肉芽肿”这一术语。本文描述了41例此前未报告的病例。组织学检查显示，除嗜酸性粒细胞外还存在肥大细胞。基于肥大细胞释放嗜酸性趋化因子以及嗜酸性粒细胞可能作为细胞毒性剂的假设，提出了伴有间质嗜酸性粒细胞增多的创伤性溃疡性肉芽肿的发病机制。
