Department of Oral Medicine and Radiology, Saraswati Dental College and Hospital, Faizabad Road, Lucknow, India.
Department of Oral Pathology and Microbiology, Saraswati Dental College and Hospital, Faizabad Road, Lucknow, India.
Arch Iran Med. 2014 Jan;17(1):91-4.
Chronic ulcers of the oral mucosa are the lesions which a physician comes across frequently. "Eosinophilic Ulcer" is a rare variety of that. Eosinophilic ulcer or traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a chronic benign lesion of the oral mucosa and is a relatively recent delineated entity. Its etiopathogenesis is still uncertain but trauma seems to play a fundamental role. Clinically the lesion manifests as an isolated ulcer, showing a raised and indurated border in addition to a white or yellowish bed. Microscopically, it is characterized by diffuse polymorphic inflammatory infiltrate, rich in eosinophils, involving the superficial mucosa and the deeper muscle layer with epitheliod cells. Hereby, reporting a case of a 60-year-old female patient who presented with a chief complaint of non-healing painful ulcer on the tongue.
口腔黏膜慢性溃疡是医生经常遇到的病变。“嗜酸性溃疡”就是其中一种罕见的类型。嗜酸性溃疡或伴有间质嗜酸性粒细胞增多的创伤性溃疡性肉芽肿（TUGSE）是口腔黏膜的一种慢性良性病变，是近年来才明确的一种疾病。其病因学尚不清楚，但创伤似乎起着重要作用。临床上，病变表现为孤立性溃疡，除白色或黄色基底外，还表现为隆起且硬化的边界。镜下，其特征为弥漫性多形性炎症浸润，富含嗜酸性粒细胞，累及浅层黏膜和深层肌肉层，伴有上皮样细胞。本文报告了 1 例 60 岁女性患者，主要表现为舌部不愈的疼痛性溃疡。
