Chomette G, Laudenbach P, Auriol M, Szpirglas H
Rev Stomatol Chir Maxillofac. 1983;84(3):121-7.
139 salivary gland biopsies have been studied in patients with Sjögren's syndrome. Histologically, we classified labial salivary gland injuries (127 cases) in 3 groups based on striated duct distension: first, some tubular ectasia with few interstitial lymphoid cells; second, much ectasia associated with many lymphoid cells and early pericanalar sclerosis; third, intensive ectasia, scarce lymphocytes, severe peri and intralobular sclerosis and extensive destruction of acini. This grading is positively correlated with that of parotid biopsies and also with abnormalies on 60 parotid sialographic radiogramms performed simultaneously. Histoenzymological and ultrastructural studies demonstrate, at an early stage of the disease, epithelial and myoepithelial alterations in striated ducts, with tubular ectasia. Simultaneously, an intensive regeneration from intercalated ducts takes place. Nevertheless that regeneration fails to repair myoepithelial cells. Furthermore, young myoid cells, leaving tubular walls, migrate in interstitial tissue and are responsible for accumulation of membranoid material and later of collagen sclerosis.
对139例干燥综合征患者的唾液腺活检样本进行了研究。组织学上，我们根据纹状管扩张情况将唇腺损伤（127例）分为3组：第一组，一些小管扩张，间质淋巴细胞较少；第二组，大量扩张，伴有许多淋巴细胞和早期腺管周围硬化；第三组，严重扩张，淋巴细胞稀少，小叶周围和小叶内严重硬化，腺泡广泛破坏。这种分级与腮腺活检分级呈正相关，也与同时进行的60例腮腺涎管造影X线片上的异常情况相关。组织酶学和超微结构研究表明，在疾病早期，纹状管出现上皮和肌上皮改变，伴有小管扩张。同时，闰管发生强烈再生。然而，这种再生未能修复肌上皮细胞。此外，年轻的肌样细胞离开管壁，在间质组织中迁移，导致膜样物质积聚，随后形成胶原硬化。
