Lewis R A, Lewis M N, Tattersfield A E
Agents Actions Suppl. 1983;13:71-9.
The effect of suggestion on the airway response to ten inhalations of normal saline followed by doubling concentrations of isoprenaline was assessed in 12 normal and 30 asthmatic subjects. It was suggested that the first 5 saline solutions contained a bronchoconstrictor and the second 5 a bronchodilator, or vice-versa, and that the first four isoprenaline solutions were inert whilst the last was a bronchodilator. Nine asthmatic but no normal subjects bronchoconstricted after saline inhalation with a mean 40% fall in specific airway conductance (sGaw). This was dose-dependent and abolished when inhalations were carried out at 37 degrees C 100% relative humidity. Suggestion did not affect the airway response to saline or isoprenaline in either group. We conclude that bronchoconstriction following saline inhalation, previously attributed to the effect of suggestion, is caused by airway cooling.
在12名正常受试者和30名哮喘患者中，评估了暗示对气道对10次吸入生理盐水后再吸入双倍浓度异丙肾上腺素反应的影响。暗示前5次生理盐水溶液含有支气管收缩剂，后5次含有支气管扩张剂，或者反之，并且前4次异丙肾上腺素溶液无活性，而最后一次是支气管扩张剂。9名哮喘患者而非正常受试者在吸入生理盐水后出现支气管收缩，比气道传导率（sGaw）平均下降40%。这是剂量依赖性的，当在37摄氏度、相对湿度100%的条件下进行吸入时可消除。暗示对两组中气道对生理盐水或异丙肾上腺素的反应均无影响。我们得出结论，先前归因于暗示作用的吸入生理盐水后的支气管收缩是由气道冷却引起的。
